Press Release | Marin Biologic Labs Achieves Flawless FDA Inspection for Second Consecutive Year, Expands Biopharmaceutical Services What are PROTACs? Proteolysis Targeting Chimeric (PROTAC) drugs are innovative molecules that utilize the ubiquitin-proteasome system to selectively degrade specific proteins within cells. PROTACs are one of the most promising methods for targeted protein degradation (TDP), which is […]
Press Release | Marin Biologic Labs Achieves Flawless FDA Inspection for Second Consecutive Year, Expands Biopharmaceutical Services What are PROTACs? Proteolysis Targeting Chimeric (PROTAC) drugs are innovative molecules that utilize
What is a Cell Based Assay? A cell based assay uses live cells to quantify biological processes and evaluate cellular responses to various stimuli. These assays provide a more physiologically
Lung cancer is among the most lethal malignancies worldwide, with limited therapeutic success despite advancements in immunotherapy. Immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1 pathways, have marked a paradigm
A groundbreaking study published in the journal Cell has unveiled a pivotal role for the immune system in suppressing the spread of breast cancer (1). The research highlights how
Researchers from AstraZeneca have unveiled new insights into the behavior of trivalent proteolysis-targeting chimeras (PROTACs), challenging previous assumptions about their efficacy in targeted protein degradation. A study by Imaide et
Introduction Oncolytic viruses (OVs) represent a class of viruses that specifically target and destroy cancer cells while leaving normal healthy cells unharmed. These viruses can be either genetically modified or
Introduction PROTAC (PROteolysis TArgeting Chimera) is a novel therapeutic approach that leverages the cell’s natural protein degradation machinery to selectively target and degrade disease-causing proteins. Unlike traditional inhibitors that merely
Introduction An Antibody-Drug Conjugate (ADC) is a precision cancer therapy that harnesses the specificity of a monoclonal antibody to target cancer cells linking it to a potent cytotoxic drug via
Flow Cytometry in Cell-Based Assays and Drug Discovery: A Focus on Cytokine Analysis Flow cytometry is a powerful analytical technique that combines principles of fluid dynamics, optics, and fluorescent labeling
DO YOU NEED A GMP VALIDATED POTENCY ASSAY? Does the FDA or your Quality Department tell you that to release your manufactured lots you need a validated potency assay? Marin
