Cutting Edge MarinBio Science Newsletter
July 23, 2026
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Download the full article (PDF) Introduction Antibody oligonucleotide conjugates (AOCs) represent an emerging class of biotherapeutics that combine the cell-targeting precision of antibodies with the
Download the full article (PDF) Introduction Immunocytokines, which are fusion proteins combining a cytokine with an antibody or antibody fragment, constitute a rapidly advancing
Download the full article (PDF) Introduction The emergence of chimeric antigen receptor (CAR)-based immunotherapies has revolutionized the treatment of hematologic malignancies. While CAR-T cell therapies
Download the full article (PDF) The engineering of chimeric antigen receptor (CAR) T cells has redefined cancer immunotherapy, producing transformative clinical outcomes in hematological
Download the full article (PDF) Introduction Artificial intelligence (AI) has rapidly transformed the field of protein engineering by enabling the generation of novel protein sequences
Download the full article (PDF) Introduction Infectious diseases have shaped human civilization for millennia, often determining the fate of societies, economies, and populations. Among the
Download the full article (PDF) G protein-coupled receptors and their signaling pathways G protein–coupled receptors (GPCRs) represent one of the largest and most diverse families
Download the full article (PDF) Introduction The search for new small molecule drugs begins with a deceptively simple question: how does the structure of a
Download the full article (PDF) Chimeric Antigen Receptor (CAR) cells are genetically engineered immune cells, most commonly T cells, designed to recognize and attack specific
Download the full article (PDF) The concept that the immune system can recognize and eliminate malignant cells dates back over a century, but the
Download the full article (PDF) Introduction CAR-macrophage therapy is an emerging cancer treatment strategy that engineers macrophages to express chimeric antigen receptors (CARs),
Download the full article (PDF) Introduction Cancer is fundamentally a disease of cellular heterogeneity. Tumors are composed of genetically and phenotypically diverse malignant cells,
Download the full article (PDF) Introduction Subunit vaccines are increasingly at the forefront of cancer immunotherapy. They are termed ‘subunit’ vaccines because they are
Download the full article (PDF) MarinBio Blog Advances in Gene Therapy for Ultra-Rare Genetic Disorders Introduction Ultra-rare hereditary genetic disorders represent some of the most
Download the full article (PDF) MarinBio BLOG The CAR-Treg Rebellion Chimeric Antigen Receptor (CAR)-engineered regulatory T cells (CAR-Tregs) represent a distinct and rapidly emerging
Download the full article (PDF) INTRODUCTION Cancer remains a leading cause of morbidity and mortality worldwide, and the need for therapies capable of addressing
Introduction Cancer treatment has undergone a dramatic transformation in recent years, moving from broad cytotoxic chemotherapies toward molecularly precise strategies tailored to specific genetic,
G Protein Coupled Receptors (GPCRs) represent a vast and diverse family of membrane proteins that are central to the regulation of human immune cell
Introduction Autoimmune diseases constitute a complex group of disorders in which immune system dysregulation leads to chronic inflammation and tissue damage. Among these diseases, rheumatoid
Flow cytometry stands at the forefront of cancer diagnostics and therapeutics, transforming oncology practice through its capacity to dissect cellular and molecular complexity. By
CAR T-cell therapy represents a significant shift in the treatment landscape for cancer, particularly in hematologic malignancies. Unlike traditional immunotherapies, Chimeric Antigen Receptor (CAR) T-cells
The mixed lymphocyte reaction (MLR) is a basic immunological assay used to study T cell responses to allogeneic antigens (from different individuals). By co-culturing
Flow cytometry has emerged as a cornerstone technology in clinical trials, providing unparalleled capabilities to probe in depth characteristics of single cells simultaneously through
Introduction The early stages of metabolic and neurodegenerative disease—prediabetes, pre-obesity, and mild cognitive impairment —are indicators for increased risk of morbidity and mortality. While they
Introduction Cell-based high throughput screening (HTS) platforms have significantly accelerated drug discovery by providing high-content, scalable, and clinically relevant data early in the screening pipeline.
The landscape of cancer immunotherapy is rapidly evolving with the emergence of several cutting-edge modalities. Some examples include genetically engineered chimeric antigen receptor (CAR)
Contemporary and Mechanistically Distinct Novel Cancer Drugs Recent advances in cancer therapeutics have ushered in a new era of precision oncology, with several novel
Exosomes are small, membrane-bound vesicles released by cells that play a crucial role in cell-to-cell communication by transferring proteins, lipids, and nucleic acids such
Introduction Cancer has long been a formidable adversary, challenging scientists and clinicians alike to develop innovative strategies for treatment and management. Immuno-oncology, a field focused
Understanding the steps involved in development of T cells that can specifically target tumor cells and kill them is central to developing drugs that