Antigen-specific tolerance is a fundamental aspect of immune regulation, critical in the context of both autoimmune disease and cancer. In vitro assays using human immune cells provide a mechanistic platform to measure tolerance and evaluate candidate tolerogenic drugs. These assays differ in the immune cell types used, antigen sources, readout formats, and sensitivity to drug-induced […]
Antigen-specific tolerance is a fundamental aspect of immune regulation, critical in the context of both autoimmune disease and cancer. In vitro assays using human immune cells provide a mechanistic platform
Introduction Cell-based high throughput screening (HTS) platforms have significantly accelerated drug discovery by providing high-content, scalable, and clinically relevant data early in the screening pipeline. Cell-based assays have become indispensable
The landscape of cancer immunotherapy is rapidly evolving with the emergence of several cutting-edge modalities. Some examples include genetically engineered chimeric antigen receptor (CAR) immune cell subsets, neoantigen vaccines
In a recent article published in Molecular Therapy, researchers from Voyage Therapeutics reported the development of a novel adeno-associated virus (AAV) capsid capable of crossing the blood-brain barrier (BBB)
The U.S. Food and Drug Administration (FDA) is spearheading a transformative shift in preclinical drug safety testing through a comprehensive roadmap aimed at reducing and ultimately replacing animal studies with
The development and regulatory approval of pharmaceuticals represents one of the most rigorous scientific and administrative processes in modern healthcare. This comprehensive analysis explores the (1) historical evolution of pharmaceutical
