Antigen-specific tolerance is a fundamental aspect of immune regulation, critical in the context of both autoimmune disease and cancer. In vitro assays using human immune cells provide a mechanistic platform to measure tolerance and evaluate candidate tolerogenic drugs. These assays differ in the immune cell types used, antigen sources, readout formats, and sensitivity to drug-induced […]
Antigen-specific tolerance is a fundamental aspect of immune regulation, critical in the context of both autoimmune disease and cancer. In vitro assays using human immune cells provide a mechanistic platform
Introduction Cell-based high throughput screening (HTS) platforms have significantly accelerated drug discovery by providing high-content, scalable, and clinically relevant data early in the screening pipeline. Cell-based assays have become indispensable
The landscape of cancer immunotherapy is rapidly evolving with the emergence of several cutting-edge modalities. Some examples include genetically engineered chimeric antigen receptor (CAR) immune cell subsets, neoantigen vaccines
In the ongoing fight against cancer, new and innovative cell-based therapies continually emerge, offering hope and progress where traditional treatments may fall short. Among these groundbreaking approaches is Tumor-Infiltrating Lymphocyte
Efficacy of mRNA vaccines on SARS-CoV-2 variants (UK and South Africa) Detection of mutations arising in the genome of the SARS-CoV-2 virus responsible for COVID-19 have led to concerns that
Potential Multiple Sclerosis mRNA Vaccine BioNTech in Germany is one of two companies (the other being Moderna in the US) that have successfully developed mRNA vaccines against SARS-CoV-2, the virus
Innate Immunity and Adaptive Immunity Innate immunity is the initial immune response to infectious agents, carried out mainly by granulocytes and macrophages. These include a variety of responses that are genetically
T Cell and Innate Immune Responses to Viral Infection – Implications for the Pandemic While much of the focus on treating COVID-19 and preventing its spread has been on antibodies,
Vaccine development is protracted and risky. On average, vaccines take more than 10 years to move from the preclinical phase to approval, and the probability of market entry for any
The unprecedented scale of scientific effort being applied to countering the pandemic is already beginning to bear fruit. Current estimates of the infection fatality rate (IFR) have been lowered to
