CAR T-cell therapy represents a significant shift in the treatment landscape for cancer, particularly in hematologic malignancies. Unlike traditional immunotherapies, Chimeric Antigen Receptor (CAR) T-cells are genetically engineered T lymphocytes that can recognize specific tumor antigens independently of the major histocompatibility complex (MHC). After being redirected to identify cancer cells through an extracellular antigen-binding domain, […]
CAR T-cell therapy represents a significant shift in the treatment landscape for cancer, particularly in hematologic malignancies. Unlike traditional immunotherapies, Chimeric Antigen Receptor (CAR) T-cells are genetically engineered T lymphocytes
The mixed lymphocyte reaction (MLR) is a basic immunological assay used to study T cell responses to allogeneic antigens (from different individuals). By co-culturing peripheral blood mononuclear cells (PBMCs)
What is a Cell Based Assay? A cell based assay uses live cells to quantify biological processes and evaluate cellular responses to various stimuli. These assays provide a more physiologically
Lung cancer is among the most lethal malignancies worldwide, with limited therapeutic success despite advancements in immunotherapy. Immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1 pathways, have marked a paradigm
A groundbreaking study published in the journal Cell has unveiled a pivotal role for the immune system in suppressing the spread of breast cancer (1). The research highlights how
Introduction Oncolytic viruses (OVs) represent a class of viruses that specifically target and destroy cancer cells while leaving normal healthy cells unharmed. These viruses can be either genetically modified or
Introduction PROTAC (PROteolysis TArgeting Chimera) is a novel therapeutic approach that leverages the cell’s natural protein degradation machinery to selectively target and degrade disease-causing proteins. Unlike traditional inhibitors that merely
Introduction An Antibody-Drug Conjugate (ADC) is a precision cancer therapy that harnesses the specificity of a monoclonal antibody to target cancer cells linking it to a potent cytotoxic drug via
Flow Cytometry in Cell-Based Assays and Drug Discovery: A Focus on Cytokine Analysis Flow cytometry is a powerful analytical technique that combines principles of fluid dynamics, optics, and fluorescent labeling
DO YOU NEED A GMP VALIDATED POTENCY ASSAY? Does the FDA or your Quality Department tell you that to release your manufactured lots you need a validated potency assay? Marin
