There are three well known Extracellular Vesicles: Exosomes, Apoptotic Bodies and MicroVesicles. which bleb from the cell’s plasma membranes. Apoptotic Bodies are largest with diameters from 800 to 5000 nm. Apoptotic Bodies originate from apoptotic cells and contain fragmented cell nuclei, proteins, DNA, RNA and miRNA. MicroVesicles are smaller in size at between 50 and 1000 nm and bleb from non-apoptotic living cells. Blebbing of MicroVesicles includes trafficking of cellular molecules to the plasma membrane, which results in protrusions from cell’s surfaces, budding and then membrane detachment.