• Stable Formulation Development

    Posted on Dec 27, 2018

    There are a variety of strategies to stabilize proteins and enzymes. Storage of the proteins is investigated including lyophilization, flash freezing, normal freezing methods, and storage below 0oC with glycerol or DMSO like compounds. If kept at 2-8oC, the types of potential antibacterial reagents is determined. If kept at 2-8oC without antibacterial reagents, the method of generating a sterile protein solution without adsorption loses onto a filter is identified. The addition of stabilizing reagents is methodically studied so that bioactivity and physical conformation is not affected.