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Exosomes

In 2024, MarinBio successfully passed the FDA inspection with no 483s and no observations and in 2025 passed the EU inspection

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Our Extracellular Vesicles (EVs) & Exosomes Service Include:

Molecular Characterization

  • Western Blotting: Detects specific protein markers such as CD9 and CD63 that affect such processes of platelet aggregation, muscle cell fusion, and egg-sperm fusion, and HSP70 that facilitates the proper folding of newly translated and misfolded proteins
  • Flow Cytometry: Analyzes the surface markers of intact exosomes, allowing for phenotyping..
  • ELISA: Quantifies specific exosomal proteins using antibody-based detection.
  • PCR/RT-PCR: Analyzes the RNA and DNA content of exosomes.
 

Cell-Based Assays

Interaction with Target Cells

  • Reporter Gene Assays: Uses reporter genes to assess the functional delivery of genetic material by exosomes to target cells.
  • Migration and Invasion Assays: Evaluates the effect of exosomes on the migratory and invasive properties of cancer cells.

 Potency Assays

  • Enzymatic-Based Assays: Measures the enzymatic activity within exosomes to predict their bioactivity and integrity.
  • Immunomodulation Assays: Evaluates the ability of exosomes to modulate immune responses, such as inhibiting T-cell proliferation.
 

Drug Delivery Assays

  • Drug Loading Efficiency Assays: Quantifies the amount of therapeutic cargo loaded into exosomes using techniques like fluorescence labeling.
  • Drug Release Kinetics Assays: Measures the release profile of the therapeutic cargo from exosomes over time.
Different types of extracellular vesicles and their functions

Need Help or Have Questions on Developing Assays for Extracellualr Vesicles or Exosomes?

Contact us to discuss the specifics of your project. Our team of experienced scientists is ready to assist you with tailored solutions to meet your unique needs. Whether you need help with assay development, FDA IND, stability study,  lot release approval, or other scientific endeavors, we are here to support you.
Contact us to learn more about our cell based assay services

We will initiate your project as soon as the proposal is approved and signed by you. Our streamlined process ensures a quick start, minimizing delays and maximizing efficiency. Fill out the form below to email us or click our live chat option to speak with a MarinBio Scientist and get your project underway.

Yes, we have over 30 years of expertise in developing and validating cell based assays for FDA IND, lot release or stability study approval. Our team can also liaise directly with the FDA on your behalf, ensuring a smooth and compliant process. Please contact us to learn more about how we can assist you with your assay development and FDA approval needs.

MarinBio scientists are experienced and creative in designing, developing, validating assays. Some of the assays we perform are listed below, but there are many more that we created, developed and validated. Give us call so that we may help you.

MarinBio scientists conducting targeted protein degradation assays in advanced laboratory

Need Help or Have Questions on Developing Assays for Extracellualr Vesicles or Exosomes?

Give us a call at 415-883-8000

With 30 years of expertise, we specialize in developing in vitro and cell-based assays that are essential for drug discovery and development. Our services include:

  • Unmatched quality
  • Prompt timelines
  • Cost-effective solutions
  • Exceptional communication
 

MarinBio assists you throughout the drug development process, including IND/BLA applications, commercialization, and pharmacokinetics (PK).

We engage directly with the FDA and work closely with our clients to achieve their goals.

Exosome analysis services for drug discovery and development
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Extracellular vesicles (EVs) are membrane-bound vesicles (50-1000 nm) released by all living cells into the extracellular space.  Exosomes form inside the cell and fuse with the cell membrane to get released.  Microvesicles form near the cell exterior, are composed of cytoplasmic components, and are released by.plasma membrane budding. They contain diverse molecules such as proteins, lipids, and nucleic acids.  In addition, apoptotic bodies (500-2000 nm) are released from dying cells during apoptosis.

Exosomes and other EVs have gained attention in drug discovery and delivery due to their unique properties. 

Key applications include

  • Drug Delivery Systems: Targeted delivery of drugs, genes, or small molecules; crossing biological barriers like the cell surface and blood-brain barrier.
  • Biomarkers for Disease Diagnosis: Early detection and non-invasive monitoring of diseases using exosome-specific biomarkers.
  • Therapeutic Applications: Promoting tissue regeneration in regenerative medicine; modulating immune responses in immunotherapy.
  • Drug Resistance: Understanding and overcoming mechanisms of drug resistance in diseases like cancer.

Contact Us About Our Exosomes Services

For More Information about our Exosomes services, please use the following informational form