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Design and Validate a GMP Cell Based Assay

What is a Cell Based Assay? A cell based assay uses live cells to quantify biological processes and evaluate cellular responses to various stimuli. These assays provide a more physiologically relevant model compared to biochemical assays that just measure the concentration of the drug induced moiety, such as protein, DNA or RNA. Since cell based […]

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Design and Validate a GMP Cell Based Assay

What is a Cell Based Assay? A cell based assay uses live cells to quantify biological processes and evaluate cellular responses to various stimuli. These assays provide a more physiologically

Anti-Viral Therapy

Inhaler-Based Immunotherapy for Lung Cancer

Lung cancer is among the most lethal malignancies worldwide, with limited therapeutic success despite advancements in immunotherapy. Immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1 pathways, have marked a paradigm

Anti-Viral Therapy

Breakthrough Study Reveals Key Mechanism in Breast Cancer Metastasis Prevention

A groundbreaking study published in the journal Cell has unveiled a pivotal role for the immune system in suppressing the spread of breast cancer (1). The research highlights how

Anti-Viral Therapy

From Bench to Bedside: Oncolytic Viruses are Revolutionizing Cancer Treatment

Introduction Oncolytic viruses (OVs) represent a class of viruses that specifically target and destroy cancer cells while leaving normal healthy cells unharmed. These viruses can be either genetically modified or

Illustration of PROTAC mechanism for protein degradation

Anti-Viral Therapy

Cutting-Edge PROTACs: Ready to Transform Clinical Oncology

Introduction PROTAC (PROteolysis TArgeting Chimera) is a novel therapeutic approach that leverages the cell’s natural protein degradation machinery to selectively target and degrade disease-causing proteins. Unlike traditional inhibitors that merely

Anti-Viral Therapy

Breakthroughs in Antibody-Drug Conjugates (ADCs) Highlighted from ASCO 2024 Abstracts

Introduction An Antibody-Drug Conjugate (ADC) is a precision cancer therapy that harnesses the specificity of a monoclonal antibody to target cancer cells linking it to a potent cytotoxic drug via

Scientist working at a flow cytometry machine in Marin Biologic Laboratories, analyzing cytokine data for drug discovery

Anti-Viral Therapy

Flow Cytometry and Cytokine Analysis: Advancing Drug Discovery at Marin Biologic Laboratories

Flow Cytometry in Cell-Based Assays and Drug Discovery: A Focus on Cytokine Analysis Flow cytometry is a powerful analytical technique that combines principles of fluid dynamics, optics, and fluorescent labeling

Specialized laboratory setup for cell-based assays, showcasing high-tech equipment and professional researchers focused on advanced biotechnological research.

Anti-Viral Therapy

Beyond Precision: The Critical Role of Validated Potency Assays in Drug Development

DO YOU NEED A GMP VALIDATED POTENCY ASSAY? Does the FDA or your Quality Department tell you that to release your manufactured lots you need a validated potency assay? Marin

Photorealistic image showing ADC molecules binding to a cancer cell, illustrating the precision of cell-based assays in cancer treatment

Anti-Viral Therapy

Advancing Cancer Therapeutics: The Role of Potency Assays in ADC Effectiveness

Antibody Drug Conjugate (ADC) Drugs Kill Target Cells What is an Antibody Drug Conjugate (ADC)? What potency assays are needed for an ADC? How can Marin Biologic Laboratories help you

Photorealistic depiction of a laboratory with advanced equipment for bispecific antibody potency assays, highlighting a 96-well plate and molecular structures for cancer immunotherapy research.

Anti-Viral Therapy

Advancing Bispecific Antibody Constructs: Potency Assay Innovations at MarinBio

CANCER HIGHLIGHT | Potency Assay for Bispecific Antibody Constructs Blog Highlights: What is a bispecific antibody? How is a potency assay for a bispecific antibody for cancer immunotherapy performed? How can MarinBio