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  • Biomarker

    A biomarker is a detectable response in cells or in the body to an intervention. It can indicate a particular disease state. Biomarkers can indicate deleterious side effects of drugs, risk of progression of a disease, or susceptibility of the disease to a given treatment.

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  • Flow Cytometry

    Flow cytometry measures physical and chemical characteristics of a population of cells or particles.[1][2][3][4] A sample containing cells or particles is suspended in a fluid and injected into the flow cytometer instrument. The sample is focused to ideally flow one cell at a time through a laser beam and the light scattered is characteristic to….

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  • Gene Expression

    Gene expression, the activation of a specific gene to produce a messenger RNA that directs the synthesis of protein. Other gene expressions include RNA molecules from non-protein coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes.

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  • High Throughput Screening (HTS)

    To screen a library of thousands of compounds, a high throughput screening assay will facilitate the identification of potential “hits” in less time than a typical assay. A high throughput assay typically is not complicated, must be very reproducible and have a high signal-to-noise ratio in order to minimize false positives. The method could be….

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  • Immunophenotyping

    This technique detects specific markers on subsets of cells, e.g. tumor cells or subsets of T lymphocytes. The method may be performed on single cell samples by flow cytometry or immunofluorescent microscopy, or on tissue sections by immunohistochemistry.

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  • Potency Assay

    A potency assay is a GMP lot release assay that measures the activity of the drug in units per mg. Typically the assay is a bioassay in which increased concentrations of drug induce a sigmoid shaped response curve of a biological event. The EC50 determination defines the

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  • Protein Concentration

    Protein concentration is determined by absorbance at 280nm (aromatic amino acids) or 205nm (peptide bond), by the Bradford assay or by amino acid analysis.

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