Fibrosis is a final common pathological end-point of chronic injury in multiple organs, characterized by persistent myofibroblast activation, excessive extracellular matrix (ECM) deposition, and progressive organ dysfunction. Although triggers differ across pulmonary, hepatic, renal, cardiac, and dermal fibrosis, a conserved set of cellular and molecular mechanisms drives disease progression. Translational research has increasingly […]
Fibrosis is a final common pathological end-point of chronic injury in multiple organs, characterized by persistent myofibroblast activation, excessive extracellular matrix (ECM) deposition, and progressive organ dysfunction. Although
Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of mortality and morbidity globally. According to the Global Burden of Disease studies, COPD is among the top three causes
Abstract DNA-damaging chemotherapies remain foundational in cancer treatment and are increasingly recognized as potent modulators of anti-tumor immunity. Genotoxic stress activates innate immune sensing pathways, most prominently the
T cells play a central role in immune surveillance by recognizing and eliminating malignant cells, thereby preventing cancer initiation and progression. Through antigen-specific cytotoxic activity and the production of
Introduction Antibody–drug conjugates (ADCs) have emerged as a transformative class of targeted cancer therapies by combining the specificity of monoclonal antibodies with the cytotoxic potency of chemotherapeutic agents. Over the
The development of epigenetic therapeutics marks a fundamental shift in modern drug discovery, moving beyond permanent genetic alterations to target reversible regulatory modifications on DNA and histones. DNA methylation–targeting
Antigen-specific tolerance is a fundamental aspect of immune regulation, critical in the context of both autoimmune disease and cancer. In vitro assays using human immune cells provide a mechanistic platform
Download the full article (PDF) Introduction Metabolic diseases comprise a heterogeneous and broad spectrum of inherited or acquired disorders characterized by disruptions in normal biochemical processes that convert nutrients into
Download the full article (PDF) Antigen processing sits at a biological crossroads where the immune system decides whether to tolerate or attack. In autoimmune disease, this pathway becomes overzealous,
Download the full article (PDF) Artificial Intelligence has progressed from a supplementary analytics tool to a foundational infrastructure that now supports the full drug discovery and development spectrum. Recent, rapid
