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Large Study Finds Gene Therapy Using AAV Has a Very Low Risk of Causing Liver Cancer
Introduction Recombinant adeno-associated virus (rAAV) vectors have become the leading platform for in vivo gene therapy, transforming the treatment of numerous inherited diseases, including spinal muscular atrophy (SMA) and hemophilia. Hundreds of AAV-based therapies are currently in clinical development or have reached clinical practice because of their ability to achieve long-term gene expression […]

Recent Articles

Robin: The AI Scientist That Performs Scientific Discovery – And Discovered a New Drug Candidate for Blindness
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Large Study Finds Gene Therapy Using AAV Has a Very Low Risk of Causing Liver Cancer
Introduction Recombinant adeno-associated virus (rAAV) vectors have become the leading platform for in vivo gene therapy, transforming the treatment of numerous inherited diseases, including spinal muscular atrophy (SMA)

Editing the Powerhouse: Mitochondrial Genome Editing for Human Gene Therapy
Why Mitochondrial DNA Matters Mitochondria are the energy-producing organelles of human cells. Unlike most cellular structures, mitochondria possess their own small genome known as mitochondrial DNA (mtDNA). The

Editing the Powerhouse: Mitochondrial Genome Editing for Human Gene Therapy
Why Mitochondrial DNA Matters Mitochondria are the energy-producing organelles of human cells. Unlike most cellular structures, mitochondria possess their own small genome known as mitochondrial DNA (mtDNA). The

A New Biological Gene Clock Predicts Ageing, Disease, and How Long We Will Live
The Problem of Measuring Age Chronological age does not accurately reflect biological ageing. Two individuals of the same age can differ greatly in disease burden, functional capacity, and mortality

Robin: The AI Scientist That Performs Scientific Discovery – And Discovered a New Drug Candidate for Blindness
Researchers from FutureHouse have developed Robin, a groundbreaking multi-agent artificial intelligence system capable of autonomously generating scientific hypotheses, proposing experiments, analyzing biological data, and refining therapeutic strategies through

Can Supplements Slow Aging? Large Epigenetic Study Reveals Surprising Clues
Can a supplement make the body biologically younger? That is one of the most exciting — and controversial — questions in aging research. Chronological age moves forward at

A New Drug Combines Five Targets in One Molecule to Combat Obesity and Diabetes- and It Outperforms Ozempic in Mice
A new study published in the journal Nature describes a highly engineered metabolic drug that combines five distinct therapeutic activities into a single molecule — and in preclinical

RNA-Triggered Programmable Cell Elimination with CRISPR–Cas12a2 Technology
The selective elimination of cells based on their genetic or transcriptional identity is a longstanding challenge in biology and medicine. Whether the goal is to eradicate virally

Why Ageing Makes Cancer More Dangerous-And How Tumors Hijack Cellular Stress Pathways to Spread
A growing body of evidence suggests that ageing does far more than increase the risk of developing cancer. It fundamentally changes the biology of the disease itself. A major new

Eating Well May Slow Your Biological Clock – And Save Your Life
New research links diet quality to epigenetic aging and mortality risk in tens of thousands of Americans A growing body of research suggests that aging is not simply measured by